The bioinformatic projects are realized as colaboration of the Lehrstuhl für Mikrobiologie and the Lehrstuhl für Rechnertechnik und Rechnerorganisation at the Technical University Munich.
- Fully self-controlled generation and curation of integrated databases for rRNA and other relevant gene sequences; Development, optimization and parallelization of software for the automated design of gene probes useful for the investigation of microbial community structure.
- BIOLOG: BMBF-Project 01LC9902
- This project is aimed in the establishment and optimization of sequence and probe databases for genes and organisms which are relevant for analysis of biodiversity. To meet this components for the ARB program package are developed de novo or improved and optimized. Focus is on tools for the self-controlled update of rRNA alignments as well as on components for the automatic detection of identificator sequences in large groups of organisms. This should enable one to generate automatically sets of gene probes which are necessary for the ultra-fast characterization of the bacterial community structure of ecosystems.
- Functional genome analysis of environmentally relevant bacteria Part F
- REGX: BMBF-Project 03F0279F
- This is a multi-group project which is aimed to sequence and analyze the genomes of three environmentally relevant bacteria. Expression studies with these strains are carried out in addition to determine which genes are active at which time and under which conditions. Part F of the project comprises the development and integration of components which allow for a reliable and easy-to-use administration and rapid analysis of genome and expression data integrated in the graphical user interface of ARB. Another topic is the provision of gene and protein alignments based on the ARB genome database. Parallelization of data analysis and data base administration algorithms is intended as a strong increase of genome data is expected within the next years.
Cooperation project between Lehrstuhl für Mikrobiologie at the TU Munich and MWG-Biotech AG funded by the Bavarian Research Foundation
- Universal Chip for Microorganisms
- The project goal is the development of DNA-chips equipped with gene probes targeting rRNA genes as well as structural genes for a rapid and extensive identification of microorganisms in environmental samples. The project comprises design and preparation of the chips and the determination and evaluation of the appropriate reaction conditions necessary for a specific detection in a given sample. Concomitant, software should be developed which carries out the design, updating and evaluation of the chips' probe sets and the analysis of the complex hybridization profiles in a self-controlled manner.
For open positions in some of these projects please look at our open postions page.